Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 31st Clinical Neuroscience and Neurogenetics Conference: Mobilizing Neurons to Rehabilitate Dubai, UAE.

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Scientific Program Day 1
Scientific Program Day 2

Day 2 :

Keynote Forum

Temitope H Farombi

University College Hospital Ibadan, Nigeria

Keynote: Profiling the non-motor symptoms burden in Parkinson’s disease patients in Nigeria using non-motor symptoms questionnaires

Time : 10:00-10:45

Conference Series Neurogenetics 2018 International Conference Keynote Speaker Temitope H Farombi photo
Biography:

Temitope H Farombi is a graduate of University of Ibadan, Nigeria. She trained in Internal Medicine at the University College Hospital (UCH) and Neurology at UCH Ibadan, Nigeria. She was a Visiting Scholar to the Northwestern University Chicago, USA and has published articles in scientific journals.
 

Abstract:

There is emerging evidence that Non-Motor Symptoms (NMS) present earlier and they are associated with poor quality of life of individuals living with Parkinson’s disease. The NMS burden poses a greater care challenge to both the health workers and the caregivers. So profiled the burden of non-motor symptoms in Parkinson’s disease patients in Nigeria using a cross sectional method to study the NMS longitudinal natural histories. Specifically, the data of 61 consecutive PD patients that completed NMS questionnaire were analyzed using SPSS software. 44 (72.1%) were males while 17 (27.9%) were females. The mean age of respondents were 68.3 (9.6) and ranged from 39-82 years. The mean NMSQuest score among respondents were 12.8 (5.2). Most of the respondents had NMS burden 2(55.7%) followed by NMS burden 3 (31.2%) and NMS burden 4 (13.1%). A higher proportion of respondents with HY stage-1 had disease burden NMS 2 (71.4%) compared to those with NMS 3 (28.6%) and none had NMS 4. Those with H and Y stage-2 had a higher proportion with disease burden NMS 2 (78.4%) compared to those with NMS 3 (13.5%) and NMS 4 (8.1). For those with H and Y stage-3, a higher proportion had disease burden with NMS 3 (66.7%) compared to NMS 4 (33.3%) and none had NMS 2. All respondents with HY stage-4 had NMS 3. This difference was statistically significant with Chi-square=32.579 and p value <0.001. This shows that NMSQuest could be a useful tool to screen for NMS burden among PD patients and this can be used to tailor specific treatment for individual patient during clinic visits.
 

  • Neuro Pathology | Neuro Cardiology & Strokes, Neuro Chemistry | Nursing and Neuroscience | Ataxia | Neurogenetic Exploration | Psychiatry and Psychology | Epilepsy | Evaluation | Treatment & Management

Session Introduction

Shaheda Tabasum

Institute of Behavioral and Management Sciences, UAE

Title: Behavioral disorders in children

Time : 10:45-11:15

Speaker
Biography:

Sahida Tabassum is, professional, and compassionate counselling expert with 14 years of experience working in the education field. Highly skilled in facilitation, communication, mentoring, teaching and psychology, and holds organizational and administrative skills to enable success. Highly analytical mind, strong critical thinking abilities, and excellent perception skills to analyse a situation and provide grounded and beneficial guidance. For ongoing continuous professional development, I am currently pursuing Masters in Counselling and Psychotherapy (M.sc).She is an active Member of American Counselling Association and International Association for Counselling.
 

Abstract:

All kids tend to misbehave at times but if over a period of six months there is a noticeable patterns of misbehavior involved hostile, aggressive or disruptive or even behaviors which is not age appropriate. Then it is time to step in and guide them towards more positive direction/behavior. The most common disruptive behavior disorders are Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), Attention Deficit Hyperactivity Disorder (ADHD) and a child or adolescent may have two disorders at the same time. Other exacerbating factors can include emotional problems, mood disorders, family difficulties and substance abuse. 8% of children under the age of 12 years around the world exhibit oppositional defiant disorder with boys outnumbering girls by two to one. Some of the typical behaviors’ of a child with ODD include aggressive, irritating and disturbing attitude. Around 5% of 10 year olds are thought to have CD with boys outnumbering girls by four to one. Around one-third of children with CD also have attention deficit hyperactivity disorder. Severe symptoms of the typical behavior of a child with ODD include physical fights, use of drugs and suicidal attempts. Around two to five percent of children are thought to have attention deficit hyperactivity disorder with boys outnumbering girls by three to one. The characteristics of ADHD can include: Inattention, Impulsivity and over activity. All children with symptoms of ADHD and ODD/CD need to be assessed so that both types of problem behaviors can be treated. These children are difficult to live with and parents need to understand that they do not need to deal with their ADHD and ODD/CD child alone. Interventions such as parent training at home and behavioral support in the school can make a difference and parents should not hesitate to ask for assistance. Providing appropriate instructional supports in the classroom can also lessen disruptive behavior which include, creating an accepting and supportive classroom climate, promoting social and emotional skills, establishing clear rules and procedures, monitoring child behavior, utilizing rewards effectively, responding to mild problem behaviors consistently and effectively managing anger or aggressive behavior. Risk factors in children’s behavioral disorders related with education field are learning difficulties; problems with reading and writing are often associated with behavior problems. Common problems noticeable with students in education are Auditory processing disorder, dyscalculia, dysgraphia, dyslexia and language processing disorder. Children with intellectual disabilities are twice as likely to have behavioral disorders, non-verbal learning disorder, visual perceptual disorder, dyspraxia, insufficient intellectual functioning and impaired memory.
 

Marzia Afrin Ali Meem

Jinan University International Medical School, China

Title: Dementia

Time : 11:30-12:00

Speaker
Biography:

Marzia Afrin Ali Meem has completed his Secondary School Certificate and Higher Secondary Certificate Examination from Birsreshtha Noor Mohammad Public College, Peelkhane, Dhaka, Bangladesh and now  she is a MBBS ( Medicine Department) Student of Jinan University, School of Medicine (International School). She has a lot of interest about Dementia and in Future she wants to be a researcher about Dementia studies.
 

Abstract:

Dementia is a broad category of brain disease that cause a long-term and often gradual decrease in the ability to think and remember that is great enough to affect a person's daily functioning. Other common symptoms include emotional problems, difficulties with language, and a decrease in motivation. A person's consciousness is usually not affected A dementia diagnosis requires a change from a person's usual mental functioning and a greater decline than one would expect due to aging These diseases also have a significant effect on a person's caregivers. The most common type of dementia is Alzheimer's disease, which makes up 50% to 70% of cases. Other common types include vascular dementia (25%), Lewy body dementia (15%), and frontotemporal dementia. Less common causes include normal pressure hydrocephalus, Parkinson's disease dementia, syphilis, and Creutzfeldt–Jakob disease among others. More than one type of dementia may exist in the same person. A small proportion of cases run in families. In the DSM-5, dementia was reclassified as a neurocognitive disorder, with various degrees of severity. Diagnosis is usually based on history of the illness and cognitive testing with medical imaging and blood tests used to rule out other possible causes. The mini mental state examinationis one commonly used cognitive test. Efforts to prevent dementia include trying to decrease risk factors such as high blood pressure, smoking, diabetes, and . Screening the general population for the disorder is not recommended. There is no known cure for dementia. Cholinesterase inhibitors such as donepezilare often used and may be beneficial in mild to moderate disorder. Overall benefit, however, may be minor. There are many measures that can improve the quality of life of people with dementia and their caregivers. Cognitive and behavioral interventions may be appropriate. Educating and providing emotional support to the caregiver is important. Exercise programs may be beneficial with respect to activities of daily living and potentially improve outcomes. Treatment of behavioral problems with antipsychotics is common but not usually recommended due to the little benefit and side effects, including an increased risk of death. Globally, dementia affected about 46 million people in 2015. About 10% of people develop the disorder at some point in their lives. It becomes more common with age. About 3% of people between the ages of 65–74 have dementia, 19% between 75 and 84 and nearly half of those over 85 years of age. In 2013 dementia resulted in about 1.7 million deaths up from 0.8 million in 1990.As more people are living longer, dementia is becoming more common in the population as a whole. For people of a specific age, however, it may be becoming less frequent, at least in the developed world, due to a decrease in risk factors. It is one of the most common causes of disability among the old. It is believed to result in economic costs of 604 billion USD a year. People with dementia are often physically or chemically restrained to a greater degree than necessary, raising issues of human rights.  Social stigma against those affected is common.

Vittorio Iantorno

Neuro Spinal Hospital (UAE)

Title: Hepatolenticular Degeneration

Time : 12:00-12:30

Speaker
Biography:

Dr Vittorio Iantorno is a Consultant Neurologist with 20 Years of European experience in the Neurology field. He completed his study in Rome (Italy) and then moved to UK. He is Fellow of the Royal College of Physicians (FRCP- London, UK), Past Member of the Movement Disorder Society, Past-Councillor of Italian Medical Society of Great Britain and Member of the Emirates Neurological Society. He spent nearly two decades working in the United Kingdom in various prestigious Hospitals such as the Royal Free Hospital London and the Regional Neuroscience Centre at King’s College Hospital. For many years he served as the Head of Neurology Department for Heart of England NHS Trust - which is one of the largest Foundation Trusts in the West Midlands in UK - as Educational Co-ordinator for Neurology and also as the Chairperson of the local Movement Disorders/Parkinson’s Disease Operational Group. He has always been fascinated by Movement Disorders since early stage of his career especially by either the excess of movement or paucity of voluntary or involuntary movement patients experience with such conditions. He has been fundamental in setting Multidisciplinary Teams approach which he feels being a cornerstone in managing patients with Movement Disorders and he believes that such clinical conditions are an evolving field which will hopefully bring a better insight of the pathogenesis of the related diseases and improve clinical care for patients  

Abstract:

Some Movement Disorders represent a challenging condition for Neurologists to diagnose and treat. The basal ganglia were originally thought to be associated purely with motor control. However, dysfunction and pathology of different regions and circuits are now known to give rise to many clinical manifestations beyond the association of basal ganglia dysfunction with movement disorders. Hepatolenticular Degeneration has for a long time been of particular interest to the Neurologists. It exemplifies a specific metabolic disorder involving some special relation between hepatic cirrhosis and degeneration of the brain. The disease is a microcosm of the history of neurology, beginning with seminal clinical observations followed by pioneering work translating a specific deficiency in sheep to human treatment, and continuing on to identification of causative gene mutations. For nearly half a century the cause of the disease remained unclear and patients continued to die without definitive treatment. Things changed rapidly once the clear pathogenesis was demonstrated. Recognition of the disorder is important because effective treatment can prevent or improve disease features.

Hashil Hatif Al Hatmi

Almaha Academy, Qatar

Title: The effect time perception and emotional interference on autobiographical memories

Time : 12:30-13:00

Speaker
Biography:

Hashil Hatif Al Hatmi is self-determined, optimistic, adventurous, opened-minded, solution-oriented, multicultural, a confident public speaker, motivational, a perfume enthusiast, and enjoy professional and socialnetworking. he enjoy working with the youth. Using evidence-based practices to develop; leadership skills; team work; confidence; public speaking and presentations skills; including other aspects of personal development. The other two areas I like to focus on is their academic performance and of course their Islamic values (for Muslims youth) in order to become the best of people.
 

Abstract:

Over the past three decades studies have investigated whether people are able to look back in time and perceive themselves from a field (first-person) or observer perspective. A major field of cognitive psychology looked at time perception and memory and depended on emotional factors. The objective of the current research was to investigate the relationship of time estimations and emotional interference on autobiographical memories and whether perception of the field/observer is related to the emotional factor. Two studies were conducted. In study-1 (pilot), participants were asked to recall a positive, negative or a neutral autobiographical memory dating three to six years prior to the study. In study-2, participants were exposed to all three emotional autobiographical memory conditions during the task. Finally, each participant was asked whether they could look back and choose if they could perceive themselves as first-person (field), or observer, or both in a given event. Results on both studies rejected the hypotheses and suggested no significant results. Participants showed no differences in their objective and subjective duration judgements of the original events and whether they perceive them to be first-person, observer, or even both. These findings suggests further study in this field is needed as under certain experimental methods, emotional interferences and time perception may have an impact on one’s autobiographical memory.
 

Temitope H Farombi

University College Hospital Ibadan, Nigeria

Title: Neurogenetic and neurodegenerative in Africa

Time : 14:00-14:30

Speaker
Biography:

Temitope H Farombi is a graduate of University of Ibadan, Nigeria. She trained in Internal Medicine at the University College Hospital (UCH) and Neurology at UCH Ibadan, Nigeria. She was a Visiting Scholar to the Northwestern University Chicago, USA and has published articles in scientific journals.
 

Abstract:

Lamia F Alsubaie

King Abdulaziz Medical City, KSA

Title: Genomic testing and counseling: The contribution of next generation sequencing to epilepsy genetics

Time : 14:30-15:00

Biography:

Lamia F Alsubaie is a Senior Genetic Counselor at the National Guard Health Affairs in Riyadh, KSA since 2011 and part-time Instructor at Al-Faisal University, College of Medicine. She is working on variant calling and interpretation in genomic medicine since 2015. She holds a Master’s degree in Human Genetics and Genetic Counseling from Joan H. Marks-Human Genetic Program at Sarah Lawrence College in New York, USA. Her main areas of professional interest are cancer genetic counseling, genomic counseling and ethical challenges surrounding genetic testing and genetic information sharing.

Abstract:

Background: Next-generation sequencing (NGS) have become more accessible and widely available technology to detect genetic causations of diseases. While NGS technology has already benefited different clinical phenotypes, some areas have adapted less quickly than others, as in seizures and epileptic disorders, where genetic diagnosis were mainly based on epilepsy gene panels and not whole exome and/or genome sequencing. Method: We retrospectively analyzed 689 cases that have been sent for NGS over period of 18 months to investigate challenges in diagnosing epilepsy. Result: 74 (10.7%) cases out of 689 cases were sent for epilepsy, half of these cases have a positive family history. The results of NGS were divided as the following: 39 (52.7%) cases were negative, 26 positive cases (35%), and 11 inconclusive cases (14.8%). Out of the inconclusive and positive cases, only one gene has been detected twice in different cases. Comparative Genomic Hybridization (CGH) has been performed for all negative cases, only one case showed de novo duplication in 2q24.3. Conclusion: These findings have implications for our understanding of genetic testing approach and genetic counseling for patients affected with seizures and epilepsy disorders. The overall diagnostic yield of exome/genome sequencing in our cohort was 35%. And the main characteristics is genetic heterogeneity suggests NGS technology as suitable testing approach for seizures and epilepsy disorders. Genetic counseling for newly identified disease-causing variants depends on pedigree interpretation keeping in mind disease penetrance and variable expressivity.

Pousette Farouk

Ain Shams University, Egypt

Title: Assessment of cognitive functions in middle aged patients suffering from type 1 and type 2 diabetes mellitus

Time : 15:00-15:15

Speaker
Biography:

Pousette farouk is an Egyptian physician, worked as a specialized neurologist in Egypt in Ain Shams University hospitals since 2000 then worked in IBN Sina hospital in KUWAIT, currently I am in SAUDIA ARABIA, specialized in management of cerebrovascular stroke patients, epilepsy, movement disorders, and general neurology cases. worked in neurology, ICU management, teaching and researcher ,experienced in EEG, experienced in TCD, Masters in psychiatry from Ain Shams university, Professional Diploma in the research statistics SPSS from American university in cairo.
 

 

Abstract:

Background: Complications of diabetes mellitus have always been properly investigated and well known, however, cognitive impairment in young and middle aged diabetic patients needs to be evaluated and emphasized. Objective: To assess and evaluate impairment in different cognitive function domains, and aspects of cognitive and mental dysfunction in type 1 and type 2 young diabetic patients. Subjects and Methods: This study was done in MUST University on 40 patients suffering from diabetes mellitus for a period ranging from 5-35 years, they were stratified into 2 groups: group (A) 20 patients having type 1 DM, and group (B) 20 patients having type 2 DM. All the recruited patients underwent the following: proper history taking, neurological examination, blood pressure and BMI measurement. Laboratory investigations as fasting blood glucose and HbA1c were done. CT brain, and Neuropsychological assessment: using the following batteries: Mini-mental state examination (MMSE), Wechsler scale for memory and Hamilton scale for depression. Results:  In type 1 DM: 40% showed mild cognitive impairment in MMSE, 60% showed depression in Hamilton scale with p-value 0.38, 95%  impairment in associate learning, 75% in digit span forward, 40% in logical memory, 95% impairment in mental control using WMS. In type 2 DM: 60% showed mild cognitive impairment, 80% had depression, 95% showed impairment in associate learning, 90% in digit span forward, 50% logical memory, and 90% mental control deficit. There is a statistical significant correlation between level of HbA1c (diabetic control) and memory loss with p-value 0.002, however we couldn’t proof statistical significant correlation between glycemic control and MMSE nor with depression. Gender difference showed that 71.4 % of males had depression, 68.4% of females had depression with p-value 0.942 with no statistical significance. Conclusion: young and middle aged diabetic patients suffering from Type 1 and 2 DM have shown to have mild cognitive impairment, depression, memory problems, deficits in associate learning, digit span forward, logical memory and mental control. A negative  correlation between level of HbA1c (glycemic control) and memory assessment was found . Evidence suggests that cognitive dysfunction should be listed as one of the many complications of Diabetes mellitus.
 

Mehdi Fathi

Mashhad University, Iran

Title: Principals of hypnoanesthesia, hypnotic suggestion for intra and postoperative pain control

Time : 15:15-15:30

Speaker
Biography:

Mehdi Fathi has fellowship of Cardiac Anesthesia. He is an Associated Professor in Imam Rezqa Hospital which is central hospital of Mashhad University, Mashhad, Iran. He is also an international Lecturer in the hypnosis field and he is a Secretary of Iranian Scientific Society of Clinical Hypnosis.
 

Abstract:

Pain is an individual somatosensory-emotive experience. This emphasizes that we must deal with pain case by case because patients’ personality is different. Their cognition about pain, their competence and their life style and attitude would affect their pain perception and pain tolerance, then many of psychological intervention can help pain sensation. There are some well-known interventions for this manner including cognitive therapy, mental relaxation, biofeedback and hypnosis. Hypnosis is an attentive receptive brain state. Its principle components are absorption, dissociation and reduce peripheral awareness. Hypnoanalgesia has defined as guided imagery that may lead to dissociation to pain sensation or distortion of pain perception. Hypnotic suggestions induce hypnotic state and then hypnotherapist guides them to association of manners that associated to calmness, painless or sensation of other senses far as pain like pressure instead of pain. This suggestion may control pain during surgery. Many reports are about wide variety of surgeries that had done under hypnotic state without using anesthesia drugs (Cesarian section, labor abdominal surgery, orthopedic operation and so on). Also suggestion can lead to induce postoperative painless period. It needs to induce conditioning state during surgery and suggest patient to be pain free on postoperative period. This presentation would include some brief movies about surgeries that have done them without anesthesia just only through hypnosis and they show intra and postoperative analgesia.